Hepatic Overexpression of Abcb11 Promotes Hypercholesterolemia and Obesity in Mice
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چکیده
منابع مشابه
Hepatic overexpression of Abcb11 in mice promotes the conservation of bile acids within the enterohepatic circulation.
The bile salt export pump, encoded by ABCB11, is the predominant canalicular transport protein for biliary bile acid secretion. The level of ABCB11 expression in humans is widely variable yet the impact of this variability on human disease is not well defined. We aim to determine the effect of hepatic Abcb11 overexpression on the enterohepatic circulation (EHC) in mice. We used a stable isotope...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 2011
ISSN: 0016-5085
DOI: 10.1053/j.gastro.2011.06.062